All findings suggested that calcium dobesilate could ameliorate renal injury and there were no differences between calcium dobesilate and perindopril on the therapeutical effects. 从结果看,羟苯磺酸钙可以减轻实验大鼠肾脏损伤,作用与培哚普利无明显差别。
Conclusion Calcium dobesilate can improve microangiopathy of diabetes mellitus by inhibiting the over-accumulation of collagen IV. Calcium dobesilate may also contribute to diabetes by inhibiting expression of TIMP-1, up-regulating the rate of MMP-9/ TIMP-1. 结论羟苯磺酸钙能抑制胶原IV过度积聚、减轻肾小球基底膜增厚,这可能与抑制糖尿病大鼠肾脏TIMP1表达、上调MMP9/TIMP1比值有关。
Damien treatment group oral medicine and calcium dobesilate, in the control group was treated with calcium dobesilate. 治疗组口服中药达明饮及羟苯磺酸钙,对照组口服羟苯磺酸钙,连续服用30天。